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Article History

First Online: 22 February 2019

Compliance with Ethical Standards

: The present investigation was a prospective, Institutional Review Board-approved, observational study in adults > 65 years old. Informed written consent was obtained for every patient.

: Each author certifies that he or she, or a member of his or her immediate family, has no commercial association (i.e., consultancies, stock ownership, equity interest, patent/licensing arrangements, etc.) that might pose a conflict of interest in connection with the submitted manuscript. Rene Przkora, Michael P. Kinsky, Steve R. Fisher, Christopher Babl, Christoph E. Heyde, Terrie Vasilopoulos, Alan D. Kaye, and Elena Volpi declare no conflict of interest. Alan Kaye is on the speaker bureau for Merck and Depomed, Inc.

: This article does not contain any studies with human or animal subjects performed by any of the authors.