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Discovery of a Novel Small-Molecule Modulator for Full-length YB-1 Protein via Integrated Computational and in vitro Biophysical Approaches

Crossref DOI link: https://doi.org/10.1007/s12010-025-05492-x

Published Online: 2026-01-20

Published Print: 2026-04

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Somasundaram, Maharaja

Sakthivel, Pandaram

Sundaravel, Sakthi Sasikala

Jos, Sneha

Muthusamy, Karthikeyan

Thirunavukkarasu, Sivaraman

Andivelu, Ilangovan

Ganeshan, Mathan
Funding

Funding for this research was provided by:

Science and Engineering Research Board (EEQ/2018/001446 dated 22 March 2019))

Science and Engineering Research Board (dated 22 March 2019)

Science and Engineering Research Board (DST-FIST: SR/FST/LS-I/2017(C))

Research Foundation of Bharathidasan University (147425/ DIR-RES/URF/2022Date: 09.11.2022)

Rashtriya Uchchatar Shiksha Abhiyan (GM BMS Biological Sciences)

DST FIST
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Article History

Accepted: 10 December 2025

First Online: 20 January 2026

Declarations

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: Not applicable.

: Not applicable.

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: Not applicable.

: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper . The authors declare the following financial interests/personal relationships, which may be considered as potential competing interests. Mathan Ganeshan, Maharaja Somasundaram, Pandaram Sakthivel and Ilangovan Andivelu have patent #Structure and Preparation of YB-1 Modulator pending to Government of India. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this papers.

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