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TEAD4 and RXRA Regulate the Function of Nucleus Pulposus Cells in Intervertebral Disc Degeneration Via the TNF-α/NF-κB Pathway: An Integrated Analysis of Single-Cell RNA-Seq, Bulk RNA-Seq, and In Vitro Validation

Crossref DOI link: https://doi.org/10.1007/s12010-025-05534-4

Published Online: 2026-01-09

Published Print: 2026-03

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Yang, Liang

Liu, Hui

Pu, Jian

Hu, Yang

Deng, Yajun https://orcid.org/0000-0003-0953-6525
Yan, Xiongwei

Liu, Mingxuan
Funding

Funding for this research was provided by:

National Natural Sciences Foundation of China (82260443)

Natural Science Basic Research of Shaanxi Province (2024JC-YBQN-0924)

Xiangyang Central Hospital Institute level Scientific Research Project (2023YB08)
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Text and Data Mining valid from 2026-01-09

Version of Record valid from 2026-01-09
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Article History

Accepted: 10 December 2025

First Online: 9 January 2026

Declarations

:

: This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Committee of Xi’an Daxing Hospital (XMSB2023-0011).

: Not applicable.

: Informed consent was obtained from all individual participants included in the study.

: The authors declare that they have no conflict of interest.

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