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CircLOC375190 Promotes Mitochondrial Dysfunction and Ferroptosis in Neurons after Stroke by Stabilizing HUWE1 Through Interaction-Induced Ubiquitination and Degradation of IGF2BP2

Crossref DOI link: https://doi.org/10.1007/s12010-026-05585-1

Published Online: 2026-02-11

Published Print: 2026-04

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Wang, Jie

Zhou, XiXi

Wang, Yan

Zou, Kang

Yan, Mao

Xu, QingLin

Luo, ZiXin

Shen, Yu

Zhu, HongQuan https://orcid.org/0009-0006-4418-8879
Funding

Funding for this research was provided by:

Science and Technology Plan of Jiangxi Provincial Administration of Traditional Chinese Medicine (No.2024B0157)
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Text and Data Mining valid from 2026-02-11

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Article History

Accepted: 7 January 2026

First Online: 11 February 2026

Declarations

:

: Not applicable.

: Not applicable.

: All animal experiments were complied with the ARRIVE guidelines and performed in accordance with the National Institutes of Health Guide for the Care and Use of Laboratory Animals. The experiments were approved by the Institutional Animal Care and Use Committee of First Affiliated Hospital of Gannan Medical University (No.GN202112-08).

: Not applicable.

: The authors have no conflicts of interest to declare.

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