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Article History

Received: 12 August 2021

Accepted: 28 October 2021

First Online: 10 November 2021

Compliance with ethical standards

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: The authors declare that the current research was conducted independently. Mojca Jensterle has given lectures, received honoraria and participated in conferences, advisory boards sponsored by pharmaceutical companies including Amgen, Pfeizer, Novo Nordisk, Novartis. Andrej Janez has given lectures, received honoraria and research support, and participated on Speakers Bureaus, advisory boards and clinical trials sponsored by pharmaceutical companies including AstraZeneca, Boehringer Ingelheim, Eli Lilly, Merck Sharp & Dohme, Novo Nordisk, Medtronic and Sanofi. Manfredi Rizzo is a full-time Professor of Internal Medicine at the University of Palermo, Italy, and currently Medical Director in Novo Nordisk Eastern Europe; he has given lectures, received honoraria and research support, and participated in conferences, advisory boards and clinical trials sponsored by many pharmaceutical companies including Amgen, AstraZeneca, Boehringer Ingelheim, Kowa, Eli Lilly, Meda, Mylan, Merck Sharp & Dohme, Novo Nordisk, Novartis, Roche Diagnostics, Sanofi and Servier. None of the above had any role in this article, which has been written independently, without any financial or professional help, and reflects only the opinion of the authors, without any role of the industry.

: All subjects were informed of the study aims and provided written consent to participate in a study and have their data published in a journal article.

: The study was conducted according to the guidelines of the Declaration of Helsinki and its later amendment and was approved by the National Ethical Committee (protocol code 0120101/2018/18).