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Article History

Received: 19 October 2020

Accepted: 23 February 2021

First Online: 21 April 2021

Conflicts of Interest

: Dr. Vranceanu reported receiving funding from the Department of Defense and the National Institutes of Health and serving on the scientific advisory board for the Calm application, outside of the submitted work. Dr. Macklin reported serving on the scientific advisory boards of Biogen, Cerevance, and Stoparkinson Healthcare Systems, serving on the data safety monitoring boards of Acorda Therapeutics, Novartis Pharmaceuticals, and Takeda Pharmaceutical Company, and receiving grants from Acorda, Amylyx Pharmaceuticals, GlaxoSmithKline, Mitsubishi Tanabe Pharmaceuticals, Ra Pharmaceuticals, Biohaven Pharmaceuticals, Clene Nanomedicine, and Prilenia Therapeutics, outside the submitted work. Dr. Rosand reported receiving grants from the National Institutes of Health and OneMind and serving as a consultant for Boehringer Ingelheim, Pfizer, and New Beta Innovation, outside the submitted work. No other disclosures were reported.

: All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards. Consent was obtained from all individual participants included in the study.