Mainali, Shraddha http://orcid.org/0000-0002-9495-3843
Cardim, Danilo
Sarwal, Aarti
Merck, Lisa H.
Yeatts, Sharon D.
Czosnyka, Marek
Shutter, Lori
Article History
Received: 1 December 2021
Accepted: 1 March 2022
First Online: 6 April 2022
Conflicts of interest
: SY: National Institute of Neurological disorders (NINDS) grant funds to institution related to Strategies to Innovate Emergency Care Clinical Trials Network (SIREN) Data Coordinating Center (DCC), Brain Oxygen Optimization in Severe TBI - Phase 3 (BOOST-3) study. MC: Receives licensing fee for ICM+ (Intensive Care Monitoring) software. The remaining authors have no conflicts to disclose.
: This is a design and rationale article of an upcoming trial that will be conducted after appropriate ethical approval from participating sites. Informed consent will be used to enroll participants in this observational study.