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Article History

Received: 12 February 2024

Accepted: 16 May 2024

First Online: 13 June 2024

Conflicts of Interest

: The authors have no disclosures related to the present work. Potential conflicts of interest outside the submitted work are as follows: Massimo Filippi is editor-in-chief of the <i>Journal of Neurology</i> and associate editor of <i>Human Brain Mapping</i>, <i>Neurological Sciences</i>, and <i>Radiology</i>; received compensation for consulting services from Alexion, Almirall, Biogen, Merck, Novartis, Roche, and Sanofi; received compensation for speaking activities from Bayer, Biogen, Celgene, Chiesi Italia SpA, Eli Lilly, Genzyme, Janssen, Merck-Serono, Neopharmed Gentili, Novartis, Novo Nordisk, Roche, Sanofi, Takeda, and TEVA; received compensation for participation in advisory boards for Alexion, Biogen, Bristol-Myers Squibb, Merck, Novartis, Roche, Sanofi, Sanofi-Aventis, Sanofi-Genzyme, and Takeda; received compensation for scientific direction of educational events for Biogen, Merck, Roche, Celgene, Bristol-Myers Squibb, Lilly, Novartis, and Sanofi-Genzyme; and received research support from Biogen Idec, Merck-Serono, Novartis, Roche, the Italian Ministry of Health, the Italian Ministry of University and Research, and Fondazione Italiana Sclerosi Multipla. The other authors have nothing to disclose.

: The present study was conducted in accordance with the Helsinki Declaration (Fortaleza revision, 2013) and with European and Italian regulations about privacy. Informed consent was obtained from the patients or their representatives if incapacitated.