Mori, Takashi
Kobayashi, Shin
Tsukada, Yuichiro
Kojima, Motohiro
Kitaguchi, Daichi
Hasegawa, Hiro
Ikeda, Koji
Nishizawa, Yuji
Gotohda, Naoto
Bando, Hideaki
Tsuboi, Masahiro
Ito, Masaaki
Yoshino, Takayuki
Funding for this research was provided by:
the National Cancer Center Research Development Fund (2024-A-05)
the Advanced Research and Development Programs for Medical Innovation of the Japan Agency for Medical Research and Development (23lk0201148h0003)
Article History
Accepted: 4 September 2025
First Online: 22 September 2025
Declarations
:
: This study was performed in accordance with the Declaration of Helsinki and the Japanese Ministry of Health, Labour and Welfare Ethical Guidelines of Clinical Research for Human Beings. The study protocol was approved by the Institutional Review Board (IRB) of the National Cancer Center Hospital East (approval number: 2018-272) and was registered in the clinical trial registration system (UMIN000034557). Permission was obtained from the IRB that written consent did not need to be obtained from subjects as the nature of the study was retrospective and did not involve invasive interventions.
: TM, SK, YT, MK, DK, HH, KI, YN and NG have no conflicts of interest. HB reports research funding from Ono Pharmaceutical and honoraria from Ono Pharmaceutical, Taiho Pharmaceutical, and Eli Lilly in Japan. MT reports research grants from MSD, AstraZeneca KK, Ono Pharmaceutical CO., LTD, Bristol-Myers Squibb KK, Novartis, Eli Lilly Japan, MiRXES; consulting fee from AstraZeneca KK, Chugai Pharmaceutical CO.,LTD, MSD, Novartis; honoraria from Johnson & Johnson Japan, AstraZeneca KK, Eli Lilly Japan, Chugai Pharmaceutical CO., LTD, Taiho Pharma, Medtronic Japan, Ono Pharmaceutical CO.,LTD, MSD, Bristol-Myers Squibb KK, Novartis, Amgen KK, Daiichi-Sankyo. MI reports research funding from Cardinal Health, HIROTSU Bio Science, Sumitomo Chemical, ASAHI Surgical Robotics, Surg storage, Astellas Pharma, Olympus, Johnson & Johnson, Indivumed, EBM and Guardant Health; honoraria from Olympus, Johnson & Johnson, Covidien Japan, Kaken Pharmaceutical, Applied Medical Japan, Yakult Honsha, FUJIFILM, Otsuka Pharmaceutical and Merck BioPharma; consulting fee from Asahi Intecc. TY reports honoraria from Chugai Pharmaceutical, Takeda Pharmaceutical, Merck Biopharma, Bayer Yakuhin, Ono Pharmaceutical and MSD K.K; consulting fee from Sumitomo Corp.; and research grant from Amgen, Bristol-Myers Squibb, Chugai Pharmaceutical, Daiichi Sankyo. Eisai, FALCO biosystems, Genomedia, Medical & Biological Laboratories, Merus N.V., Molecular Health GmbH, MSD, Nippon Boehringer Ingelheim, Ono Pharmaceutical, Pfizer Japan, Roche Diagnostics, Sanofi, Sysmex, Taiho Pharmaceutical and Takeda Pharmaceutical.