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Article History

Received: 11 June 2020

Accepted: 14 September 2020

First Online: 24 September 2020

Compliance with Ethical Standards

:

: The authors declare that they have no conflict of interest.

: Animal experiments were conducted in accordance with the European guidelines (European Council Directives 2010/63/UE and 90/219/CEE, Regulation (EC) No. 1946/2003) and Spanish national laws on laboratory animal welfare (Royal Decrees 53/2013 and 1386/2018, Law 32/2007) and approved by the Experimentation Ethics Committees of the University of Malaga and the Biomedical Research Institute of Málaga. In relation to the human samples, the study was approved by institutional ethical committees (Comite de Ética de la Investigación provincial de Málaga), French Ethics Committee, and the French Ministry of Research, and conducted according to international ethical principles contained in the Declaration of Helsinki (Fortaleza, 2013), Spanish regulations on biomedical research (Law 14/2007, of July 3, on biomedical research), and the provisions of the European General Personal Data Protection Regulation (Royal Decree-Law 5/2018, of 27 July, and Regulation (EU) 2016/679, of April 27, 2016).

: The samples were provided by the Biobank of our hospital, as part of the Andalusian Public Health System Biobank, and the Pitié-Salpêtrière Hospital. All patients participating in the study gave their informed consent and protocols were approved by institutional ethical committees (Comite de Ética de la Investigación provincial de Málaga), French Ethics Committee, and the French Ministry of Research.