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Authors
da Rocha, Joana F.
Bastos, Luísa
Domingues, Sara C.
Bento, Ana R.
Konietzko, Uwe
da Cruz e Silva, Odete A. B.
Vieira, Sandra I. http://orcid.org/0000-0003-1053-1107
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Article History
Received: 11 June 2020
Accepted: 17 September 2020
First Online: 2 October 2020
Compliance with Ethical Standards
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: The authors declare that they have no conflict of interest.
: All authors have approved the final version of the manuscript and give their consent to be published.
: The experiments including rodent brain lysates have followed the European legislation for animal experimentation, namely the 2010/63/EU and Council Directive 86/609/EEC. The experiments were approved and supervised by our Institutional Animal Care and Use Committee (IACUC): Comissão Responsável pela Experimentação e Bem-Estar Animal (CREBEA), and followed the 3R’s (Replacement, Reduction and Refinement) guidelines. The number of animals used and the suffering was minimized. The animals were housed under a controlled environment and their health status and well-being monitored daily. Under the EU guidelines, no specific ethics approval was required for this project since the rats were not manipulated and only euthanized by cervical stretching followed by decapitation, for brain removal.
