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Precocious White Matter Inflammation and Behavioural Inflexibility Precede Learning and Memory Impairment in the TgAPP21 Rat Model of Alzheimer Disease

Crossref DOI link: https://doi.org/10.1007/s12035-021-02476-w

Published Online: 2021-07-07

Published Print: 2021-10

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Levit, Alexander https://orcid.org/0000-0003-2921-4339
Gibson, Andrew

Hough, Olivia

Jung, Youngkyung

Agca, Yuksel https://orcid.org/0000-0002-9883-3291
Agca, Cansu https://orcid.org/0000-0001-6641-7448
Hachinski, Vladimir https://orcid.org/0000-0002-0487-734X
Allman, Brian L. https://orcid.org/0000-0001-8793-2019
Whitehead, Shawn N. https://orcid.org/0000-0003-4728-8067
Funding

Funding for this research was provided by:

Natural Sciences and Engineering Research Council of Canada (435819)

Natural Sciences and Engineering Research Council (418489)

Canadian Institutes of Health Research (126127)

Canadian Consortium on Neurodegeneration in Aging

Canadian Foundation for Innovation (34213)
License Information

Text and Data Mining valid from 2021-07-07

Version of Record valid from 2021-07-07
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Article History

Received: 4 December 2020

Accepted: 26 June 2021

First Online: 7 July 2021

Declarations

:

: Animal ethics and procedures were approved by the Animal Care Committee at Western University (protocol 2014–016) and are in compliance with Canadian and National Institute of Health Guides for the Care and Use of Laboratory Animals (NIH Publication #80–23).

: Not applicable.

: First author holds copyright to data and figures reproduced from dissertation submitted to the University of Western Ontario.

: The authors declare no competing interests.

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