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Article History

Received: 17 September 2022

Accepted: 31 May 2023

First Online: 4 August 2023

Declarations

:

: The animal study protocol was reviewed and approved by the Animal Ethics Committee of Zhejiang Chinese Medical University (ZSLL, 2017–183).

: Not applicable.

: Not applicable.

: The authors declare no competing interests.

: A small part of the data in this article is consistent with the data in Wu et al. (). In Wu et al. () and this article, the authors observed consistent data regarding the paw withdrawal threshold and conditioned place aversion score in the saline group. However, the primary focus of the article by Wu et al. () was to investigate the underlying central neural mechanisms of pain aversion and the effect of electro-acupuncture. The authors’ aim was to understand the functional mechanisms of electro-acupuncture. On the other hand, this article () aimed to further explore the central neural mechanisms of pain aversion. The authors specifically investigated the potential link between pain aversion modulation and the excitability of glutamate neurons. The findings indicated that pain aversion induces significant biological changes in the amygdala.Considering the distinct research objectives of both articles, the authors made the decision not to aggregate the data in order to maintain clarity regarding the research topics and perspectives of each article.