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Conservation of vCJD Strain Properties After Extraction and In Vitro Propagation of PrPSc from Archived Formalin-Fixed Brain and Appendix Tissues Using Highly Sensitive Protein Misfolding Cyclic Amplification

Crossref DOI link: https://doi.org/10.1007/s12035-023-03444-2

Published Online: 2023-07-13

Published Print: 2023-11

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Suleiman, Suzanne

McGuire, Lynne I.

Chong, Angela

Ritchie, Diane L.

Boyle, Aileen

McManus, Lee

Brydon, Fraser

Smith, Colin

Knight, Richard

Green, Alison

Diack, Abigail B.

Barria, Marcelo A. https://orcid.org/0000-0003-4789-7401
Funding

Funding for this research was provided by:

Details described in the manuscript
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Article History

Received: 14 February 2023

Accepted: 13 June 2023

First Online: 13 July 2023

Declarations

:

: Human tissue Ethics statement: All human tissue samples examined in this study were of UK origin and were provided by the National CJD Research & Surveillance Unit (NCJDRSU), which is part of the MRC Edinburgh Brain & Tissue Bank (Edinburgh Brain Bank 16-ES-0084). Appropriate consent and ethical approval for retention and research use applies.Animal Ethics statement: All mice were housed within a derogated CL3 facility at The Roslin Institute, University of Edinburgh. Animal studies were conducted according to the regulations of the UK Home Office Animals (Scientific Procedures) Act 1986 under PPL PP6905450.

: Not applicable.

: The authors declare no competing interests.

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