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Metformin Improves Spatial Memory and Reduces Seizure Severity in a Rat Model of Epilepsy and Alzheimer’s Disease comorbidity via PI3K/Akt Signaling Pathway

Crossref DOI link: https://doi.org/10.1007/s12035-025-04844-2

Published Online: 2025-03-24

Published Print: 2025-08

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Alves, Suélen Santos

Rossi, Letícia

de Oliveira, Jose Antonio Cortes

Servilha-Menezes, Gabriel

Grigorio-de-Sant’Ana, Mariana

Mazzei, Rodrigo Focosi

Almeida, Sebastião Sousa

Sebollela, Adriano

da Silva Junior, Rui Milton Patrício

Garcia-Cairasco, Norberto https://orcid.org/0000-0001-8857-3775
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Article History

Received: 15 October 2024

Accepted: 12 March 2025

First Online: 24 March 2025

Declarations

:

: Experiments were performed in accordance to the National Institutes of Health (NIH) guidelines for the care and use of laboratory animals and approved by local government authorities (Commission for Ethics in Animal Experimentation of the Ribeirão Preto Medical School at the University of São Paulo—protocol number CEUA 1293/2024).

: The authors declare no competing interests.

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