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Isorhamnetin Alleviates Early-Life Stress-Induced Anxiety and Depression in Male Mice: Neuroinflammatory Modulation and Sirt1/NF-κB Signaling Insights

Crossref DOI link: https://doi.org/10.1007/s12035-025-05483-3

Published Online: 2025-11-29

Published Print: 2026-01

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Qnais, Esam

Gammoh, Omar

Alqudah, Mohammad

Al-Bzour, Manal

Wedyan, Mohammed

Alqudah, Abdelrahim

Alnakhli, Anwar M.

Shilbayeh, Sireen Abdul Rahim

Aljabali, Alaa A. A.

Hatahet, Taher https://orcid.org/0000-0003-0171-3304
Funding

Funding for this research was provided by:

The Hashemite University (49/2020)

Yarmouk University (2/2024)
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Text and Data Mining valid from 2025-11-29

Version of Record valid from 2025-11-29
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Article History

Received: 11 September 2024

Accepted: 5 August 2025

First Online: 29 November 2025

Declarations

:

: Animal experimental procedures were approved by the animal ethics committee at the Hashemite University (IRB number: 22/2/2024/2025), and were in accordance with the guidelines of the US National Institutes of Health on the use and care of laboratory animals, and with the Animal Research: Reporting of in Vivo Experiments (ARRIVE) guidelines.

: The authors declare no competing interests.

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