Funding for this research was provided by:
National Natural Science Foundation of China (81373136, 81572010)
National Thirteenth Five-Year Special Grand Project for Infectious Diseases (2017ZX10302201-001)
Application Research of Capital Clinical Characteristic and Promotion of Achievements (Z151100004015011)
Text and Data Mining valid from 2018-03-01
Received: 23 November 2017
Accepted: 15 March 2018
First Online: 12 April 2018
Compliance with ethical standards
: Fan Li, Xiaodong Li, Tao Yan, Yan Liu, Yongqian Cheng, Zhihui Xu, Qing Shao, Hao Liao, Pengyu Huang, Jin Li, Guo-Feng Chen, and Dongping Xu have declared that no competing interests exist.
: This study was approved by the Ethics Committee of Beijing 302 Hospital. All patients provided their informed consent for the use of their samples for research before enrollment in the Database of Beijing 302 Hospital.
: Technical appendix, statistical code, and data set are available upon request of the corresponding author Dongping Xu (xudongping302@ sina.com). The information of HBV genetic sequences with preS deletion is freely available from GenBank (KX534108-KX534166). Raw data are available from the Ethics Committee of the Beijing 302 Hospital (Beijing, China) for researchers who meet the criteria for access to confidential database.