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Article History

Received: 26 September 2019

Accepted: 27 September 2019

First Online: 9 October 2019

Compliance with ethical standards

:

: F Bautista had a consultant or advisory role for Bayer, Amgen and EusaPharma, received honoraria for speaking at symposia from Amgen and Jazz Pharmaceuticals and support for attending symposia from Takeda, EusaPharma, Shire and Jazz Pharmaceuticals. A. Cañete had a consultant or advisory role for Bayer and EusaPharma and received support for attending symposia from Nestle. A Cañete is a member of the Executive Committee of SIOPEN, non-profit organization that receives royalties for the sales of dinutuximab beta. J. L. Fuster had a consultant or advisory role for Amgen, Jazz Pharmaceuticals and Novartis. He received honoraria for speaking at symposia from Amgen, Servier, Jazz Pharmaceuticals and Pfizer and support for attending symposia from Servier and Jazz Pharmaceuticals. I. Astigarraga had a consulting or advisory role for Novartis and Amgen. S. Rives had a consulting or advisory role for Novartis, Celgene, Amgen, JazzPharma, Shire and Servier. She received honoraria for educational events and travel expenses from Novartis, Celgene, JazzPharma, Shire and Amgen. She is member of the SSC Committee of the Novartis Clinical trial EudraCT Number: 2017-002116-14 and received honoraria from Novartis. J. Dapena had a consulting or advisory role for Novartis, Servier, Amgen, Jazz Pharmaceuticals, Shire and Sobi. A. Catalá had a consultant or advisory role for Novoinmune and received support for educational events and attending symposia from Novartis and Celgene. He is a beneficiary of a research grant from Instituto de Salud Carlos III. L. Moreno had a consulting or advisory role for Novartis, AstraZeneca, Roche Genentech, Bayer, Amgen, MundiPharma. He received honoraria from Celgene and Novartis for educational events and travel expenses from MundiPharma, Celgene, Amgen. L Moreno is a member of the Executive Committee of SIOPEN, non-profit organization that receives royalties for the sales of dinutuximab beta. A. Fernández-Teijeiro had a consulting or advisory role for Amgen, Novartis and Takeda. She received honoraria from Takeda and Amgen for educational events and travel expenses from Servier, Shire and Gilead. The rest of the authors declare that they have no conflict of interest.

: ECLIM-SEHOP is supported by the grant “Cáncer infantil y cánceres poco frecuentes 2018” from Asociación Española Contra el Cáncer (AECC) (Grant CICPF18016FERN 2018), Fundación Inocente Inocente, Federación Española de Padres de Niños con Cáncer, Asociación Pablo Ugarte and Fundación MAR. Other academic clinical trials conducted in Spain are supported by many non-profit organizations to which we are also infinitely grateful as well as the SCReN platform.

: All human studies had been approved by the appropriate ethics committee and had, therefore, been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments.

: Parents and/or legal guardians of children and adult patients participating in these clinical trials gave their informed consent prior to their inclusion in the studies reported in this manuscript.