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Article History

Received: 5 July 2023

Accepted: 5 September 2023

First Online: 4 October 2023

Declarations

:

: Lena Weiss has received honoraria for scientific presentations from Roche and Servier and travel accommodation expenses from Amgen. Volker Heinemann received honoraria for talks and advisory board role for Merck, Amgen, Roche, Sanofi, Servier, Pfizer, Pierre-Fabre, AstraZeneca, BMS; MSD, Novartis, Terumo, Oncosil, NORDIC, Seagen, GSK. Research funding from Merck, Amgen, Roche, Sanofi, Boehringer-Ingelheim, SIRTEX, Servier. Anke Reinacher-Schick received honoraria from Amgen, Roche, Merck Serono, BMS, MSD, MCI Group, Astra Zeneca, for advisory and consultancy Amgen, Roche, Merck Serono, BMS, MSD, Astra Zeneca, Pierre Fabre, Research grant/Funding Roche, Celgene, Ipsen, Amgen, Alexion Pharmaceuticals, Atra Zeneca, Lilly, Servier, AIO Studien gGmbH, Rafael Pharmaceutics, Erytech Pharma, BioNTech, Travel expenses Roche, Amgen, Pierre Fabre. Jens T. Siveke receives honoraria as consultant or for continuing medical education presentations from AstraZeneca, Bayer, Boehringer Ingelheim, Bristol-Myers Squibb, Immunocore, MSD Sharp Dohme, Novartis, Roche/Genentech, and Servier. His institution receives research funding from Abalos Therapeutics, AstraZeneca, Boehringer Ingelheim, Bristol-Myers Squibb, Celgene, Eisbach Bio, and Roche/Genentech; he holds ownership and serves on the Board of Directors of Pharma15, all outside the submitted work. Michael Stahl received honoraria from Lilly. Klara Dorman has received travel support from Servier, GSK, and BMS, as well as honoraria from AstraZeneca. Danmei Zhang received honoraria from Astra Zeneca. Stefan Boeck had a consulting and advisory role for Celgene, Servier, Incyte, Fresenius, Janssen-Cilag, AstraZeneca, MSD, and BMS, and received honoraria for scientific presentations from Roche, Celgene, Servier, and MSD. Michael Haas has received travel support from servier and honoraria for scientific presentations from Falk Foundation. All other authors declare no conflict of interest.

: All 5 clinical trials reported here were conducted in accordance with the principles of the Declaration of Helsinki, the International Conference on Harmonisation Good Clinical Practice guidelines, and local regulatory requirements. All study protocols were reviewed and approved by the lead Ethics Committee of Ludwig-Maximilians-University, Munich, Germany and additionally by the Ethics Committees of the participating centers. Written informed consent for trial participation and for publication of trial results was obtained from each patient before any study specific procedure.