Document is current

Article History

Received: 1 September 2025

Accepted: 28 October 2025

First Online: 19 November 2025

Declarations

:

: The submitted article is our own, and not an official position of the institutions or funder we work at. Dr. Carlos López López reports grants and consultant fees from Bayer, grants and consultant fees from Eisai, grants and consultant fees from Pfizer, grants and consultant fees from Ipsen, grants and consultant fees from Novartis, grants and consultant fees from Lilly, during the conduct of the study; Dr. Marcel Sambo reports grants and consultant fees from Eisai, during the conduct of the study; Dr. Lorenzo Orcajo Rincón and Dr. Julio Rodríguez-Villanueva García report employees from Eisai, with interests outside the submitted work; Dr. Marta Llanos reports consultant fees from Roche, consultant fees from Amgen, consultant fees from Eisai, consultant fees from Ipsen, consultant fees from Servier, consultant fees from Lilly, consultant fees from Merck, outside the submitted work; Dr. Elena Navarro-González reports consultant fees from Eisai, during the conduct of the study; Dr. Javier Aller reports consultant fees and non-financial support from Eisai, during the conduct of the study; consultant fees from Eisai, consultant fees and non-financial support from Ipsen, consultant fees and research grants from Lilly, consultant fees and research grants from Bayer, outside the submitted work; Dr. Guillermo Crespo reports grants from Ipsen, grants from Roche, grants from BMS, grants from Eisai, grants from Sanofi, grants from Janssen, grants from Eusa Pharma, grants from Pierre Fabre, outside the submitted work; Dr. Cintia González reports other from Hospital Santa Creu i Sant Pau, during the conduct of the study; Dr. Miguel Navarro reports consultant fees and non-financial support from Ipsen, non-financial support from Novartis, consultant fees and non-financial support from Bayer, outside the submitted work; Dr. Javier Valdivia reports consultant fees from Novartis, MSD, Roche and Eisai during the conduct of the study; Dr. María José Villanueva reports consultant fees from Novartis, and GSK, outside the submitted work; Dr. Iñaki Argüelles reports consultant fees from Eisai, outside the submitted work; Dr. Juan Antonio Vallejo Casas reports grants, consultant fees and non-financial support from Eisai, during the conduct of the study; consultant fees and non-financial support from Sanofi, consultant fees from Bayer, consultant fees and non-financial support from Novartis, outside the submitted work; The remaining authors Dr. Manuel Durán-Poveda, Dr. Rita Joana Santos, Dr. Virginia Pubul, Dr. Sonsoles Guadalix, Dr. Carles Zafón, Dr. Javier Santamaría-Sandi, Dr. Ángel Segura, Dr. Pablo Gajate, Dr. Marcelino Gómez-Balaguer, Dr. Jordi Reverter, Dr. Juan Carlos Galofré, and Dr. Beatriz Castelo have nothing to disclose.