Ohmachi, Ken
Tobinai, Kensei
Kinoshita, Tomohiro
Ishikawa, Takayuki
Hatake, Kiyohiko
Ichikawa, Satoshi
Ohmine, Ken
Kamitsuji, Yuri
Choi, Ilseung
Chou, Takaaki
Tsukasaki, Kunihiro
Kumagai, Kyoya
Taniwaki, Masafumi
Uchida, Toshiki
Kikukawa, Yoshitaka
Kubo, Kohmei
Mihara, Keichiro
Tsukamoto, Norifumi
Izutsu, Koji
Yoshida, Isao
Ishida, Fumihiro
Usui, Noriko
Iida, Shinsuke
Murayama, Tohru
Ueda, Eisuke
Kuriki, Hiroshi
Ando, Kiyoshi
Funding for this research was provided by:
Chugai Pharmaceutical Co Ltd.
F. Hoffmann-La Roche Ltd.
Article History
Received: 11 January 2018
Revised: 3 July 2018
Accepted: 11 July 2018
First Online: 19 July 2018
Compliance with ethical standards
:
: KO reports personal fees from Chugai Pharmaceutical Co Ltd, Kyowa Hakko Kirin Co Ltd, Eisai Co Ltd, Pfizer Inc and Takeda Pharmaceutical Co Ltd. KT reports Grants and personal fees from Chugai Pharmaceutical Co Ltd/Roche, Celgene, Eisai, Janssen Pharmaceuticals, Kyowa Hakko Kirin, Mundipharma, Ono Pharmaceutical and Takeda; Grants from Abbvie, GlaxoSmithKine and Servier; and personal fees from HUYA Bioscience and Zenyaku Kogyo. TK reports Grants and personal fees from Chugai Pharmaceutical Co Ltd, Ono, Gilead, MSD and Zenyaku; Grants from Takeda and Solaisia; and personal fees from Bristol, Kyowa Kirin, Eisai and Janssen. TI, KKumagai, SI, YK, IC, TC, YK, KKubo, KM and NT report no conflicts of interest. KH reports Grants from Chugai Pharmaceutical Co. KO reports Grants and personal fees from Chugai Pharmaceutical Co Ltd and Takara-Bio Inc; and personal fees from Kyowa Hakko Kirin Co Ltd, Ono Pharmaceutical Co Ltd, Bristol-Meyers Squibb, Chugai Pharmaceutical Co Ltd and Alexion Pharmaceuticals Inc. KT reports Grants from Chugai Pharmaceutical Co Ltd, Celgene, Takeda and Mundipharma; consultancy from Huya and Ono Pharma, and lecture fees from Zenyaku Kogyo, Celgene, Huya, Kyowa Hakko Kirin and Chugai Pharmaceutical Co Ltd. MT reports Grants and personal fees from Chugai/Roche, Celgene, BMS, and Janssen Pharmaceuticals; Grants from Kyowa Hakko Kirin; and personal fees from Mundipharma. TU reports personal fees from Janssen Pharmaceuticals, Mundipharma, Celgene, Teijin, Novartis, Nippon Shinyaku, Pfizer, Briston-Myers Squibb, and Meiji Seika Pharama. KI reports Grants from Kenyaku Kogyo, Mundhi, Abbvie, Solasia, Celltrion, Symbio, Astellas, Astellas Amgen, Novartis and Sanofi; Grants and personal fees from Takeda, Eisai, Chugai Pharmaceutical Co Ltd, Gilead, Janssen, Ono, Celgene, MSD, Bayer and Daiichi-Sankyo, personal fees from Kyowa Hakko Kirin; and discloses a relationship with HUYA Bioscience International. IY reports research funding and honoraria from Kyowa Hakko Kirin; research funding from Chugai; and honoraria from Celgene. FI reports Grants and personal fees from Chugai Pharmaceutical Co Ltd, Kyowa Hakko Kirin, and Takeda; Grants from Bristol-Myers-Squibb; and personal fees from Celgene. NU reports research Grants from AMED, Pfizer Co, Sysmex Co, Kyowa Hakko Kirin Co, Bristol-Myers-Squibb, Novartis, Nippon Shinyaku, Fujimoto and Celgene; payment for data monitoring committee membership from CIMIC Co, Takeda Bio Development Center, Lilly Japan, Pfizer Co, Nippon Boehringer-Ingelheim Co, Janssen Pharmaceutical Co, Zenyaku Kogyo Co, Kyowa Hakko Kirin Co, Otsuka Pharm Co, Celgene Co, SymBio Pharmaceutical Co, Huya Bioscience International, and Astellas Pharmaceutical Co; and payment for speaker’s bureau for Chugai Pharmaceutical Co Ltd and Bristol-Myers-Squibb. SI reports Grants from Chugai Pharmaceutical Co Ltd, Kyowa Hakko Kirin, Astellas, Toyama Chemicals, Teijin Pharma, Sanofi, Bayer, J-Pharma, Eli Lilly, and Daiichi Sankyo; and Grants and personal fees from Ono, Janssen, Celgene, Bristol-Myers-Squibb, Novartis, and Takeda. TM reports personal fees from Bristol-Myers-Squibb, Celgene, Esai, Janssen Pharmaceutical, Kyowa Hakko Kirin, Nippon Shinyaku, Novartis, Ono Pharmaceuticals, Otsuka Pharmaceuticals, Pfizer, Sanofi, Siemens Healthcare Diagnostics, Sumitomo Dainippon Pharma, and Taiho Pharmaceutical. EU and HK are employees of Chugai Pharmaceutical Co Ltd. HK reports stock ownership for Chugai Pharmaceutical Co Ltd. KA reports subsidies or donations from Meiji Seika Pharma Co Ltd, Takeda Pharmaceutical Co Ltd, Eizai Co Ltd, Kyowa Kirin and the Japan Blood Products Organization.