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Authors
Yoon, Sung-Soo https://orcid.org/0000-0003-2591-7459
Chen, Chih Cheng
Lee, Sung-Eun
Chang, Hung
Cheong, June-Won
Hou, Hsin-An
Lee, Won Sik
Lim, Sung-Nam
Moon, Joon Ho
Ong, Kiat Hoe
Dai, Yi
Liu, Chang
Kawashima, Jun
Goh, Yeow Tee
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Funding
Funding for this research was provided by:
Sierra Oncology
GSK
Seoul National University Hospital
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Article History
Received: 4 February 2025
Revised: 2 July 2025
Accepted: 4 July 2025
First Online: 21 July 2025
Declarations
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: S-SY has provided consultancy to Amgen, Janssen, Novartis, and Sanofi, and research funding from Genentech and Pharos iBio. CCC reports no conflicts of interest. S-EL reports no conflicts of interest. HC reports no conflicts of interest. J-WC reports no conflicts of interest. H-AH has received research support from Abbvie, BMS, Celgene, Kirin and PharmaEssential and honorarium/travel/consultancy from Abbvie, Astellas, BeiGene, BMS, Celgene, Chugai, CSL Behring, Daiichi Sankyo, IQVIA, Johnson & Johnson, Kirin, Lotus, Merck Sharp & Dohme, Novartis, Ono, Panco healthcare Co., Pfizer, PharmaEssential, Roche, Synmosa, Takeda, TSH Biopharm, TTY Biopharm Company and Zuellig Pharma. WSL reports no conflicts of interest. S-NL reports no conflicts of interest. JHM reports no conflicts of interest. KHO has served on a Janssen Oncology Advisory Board. YD is an employee of GSK.
: This study was performed in accordance with the Declaration of Helsinki and the International Council for Harmonisation guidelines on Good Clinical Practice. Institutional review boards or independent ethics committees at each site approved the protocol, including the National Health Group Domain Specific Review Board, Seoul National University Hospital Institutional Review Board, Institutional Review Board of Yonsei University Health System, Severance Hospital, Institutional Review Board of Inje University Busan Paik Hospital, Kyungpook National University Hospital Institutional Review Board, Inje University Haeundae Paik Hospital Institutional Review Board, The Catholic University of Korea, Seoul St. Mary’s Hospital Institutional Review Board, Chang Gung Medical Foundation Institutional Review Board, and the Research Ethics Committee of National Taiwan University Hospital. All participants provided written consent. A data monitoring committee reviewed study progress, safety data, and critical efficacy endpoints every six months.
