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Flurbiprofen restores rifampicin and isoniazid sensitivity in multidrug-resistant Mycobacterium tuberculosis putatively by inhibiting efflux pumps Rv0194 and Rv0933

Crossref DOI link: https://doi.org/10.1007/s12223-025-01319-8

Published Online: 2025-09-22

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Elango, Padmasini

Nirmal, Christy Rosaline

Rajadas, Sam Ebenezer

Ravi, Rajkumar

Chilamakuru, Naresh Babu

V. N., Azger Dusthackeer
Funding

Funding for this research was provided by:

National Institute for Research in Tuberculosis (Fellowship/Bact/RA/Padmasini/31.10.2022, F.No. 3/1/3/PDF(21)/2019-HRD dt 18.03.2020, No. Fellowship/TB/40/2020-7030)
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Article History

Received: 28 March 2025

Accepted: 7 August 2025

First Online: 22 September 2025

Declarations

:

: This study was approved by the Institutional Ethics Committee of the ICMR-National Institute for Research in Tuberculosis (NIRT, Chennai) before its implementation (No: 021/NIRT-IEC/2021; dtd 25/2/2021).This study was also submitted and issued approval from the institutional bioethics committee for Category III as per the guidelines of DBT held at ICMR NIRT, Chennai, on 06/10/2021.

: The authors declare no competing interests.

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