Aoyama, Yosuke https://orcid.org/0000-0003-0081-9115
Ozaki, Yukinori https://orcid.org/0000-0002-8064-648X
Kuno, Masahiro https://orcid.org/0009-0005-7328-6729
Kizawa, Rika
Masuda, Jun https://orcid.org/0000-0002-0972-1926
Nishimura, Meiko https://orcid.org/0000-0002-7285-9426
Kurata, Mami
Inagaki, Lina https://orcid.org/0009-0001-9290-6816
Hosonaga, Mari
Fukada, Ippei https://orcid.org/0000-0001-7272-3708
Maeda, Tetsuyo
Yoshida, Kazuyo
Yamashita, Nami https://orcid.org/0000-0001-7182-1090
Kobayashi, Takayuki https://orcid.org/0000-0001-5257-3247
Takano, Toshimi https://orcid.org/0000-0002-8417-5291
Ueno, Takayuki https://orcid.org/0000-0002-9080-9377
Article History
Received: 2 July 2026
Accepted: 11 August 2026
First Online: 2 September 2026
Declarations
Conflict of interest: Yosuke Aoyama has received honoraria for lectures from Taiho, MSD, Pfizer, Eli Lilly, Daiichi Sankyo, Eisai, Kyowa Kirin, Chugai Pharmaceutical, and Gilead Sciences. Yukinori Ozaki has received honoraria from Eli Lilly, Pfizer, Daiichi Sankyo, AstraZeneca, Chugai, and Kyowa Kirin. Jun Masuda received honoraria from AstraZeneca, Chugai Pharmaceutical, Daiichi Sankyo, Kyowa Kirin, and Nippon Kayaku and consulting/advisory fees from Eli Lilly and SB-TEMPUS. Meiko Nishimura has received honoraria from MSD, Daiichi Sankyo, Pfizer, Eisai, Kyowa Kirin, Chugai Pharmaceutical, and Eli Lilly Japan K.K. Toshimi Takano received honoraria from Daiichi-Sankyo, Eli Lilly, Gilead Sciences, and MSD. Takayuki Ueno received honoraria for lectures from Chugai Pharmaceutical Co., Ltd., AstraZeneca K.K., Guardant Health Japan Corp., Daiichi Sankyo Co., Ltd., and Exact Sciences Co., and a grant from Eli Lilly Japan K.K. and Gilead Sciences, Inc.
Ethical approval: Ethical approval was obtained from the Ethics Board of Cancer Institute Hospital, Japanese Foundation for Cancer Research (approval number 2023-GB-051). All procedures were performed in accordance with the ethical standards of the Institutional Research Committee and the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.
Consent to participate: Because of the retrospective nature of the study, patients from whom written informed consent could not be obtained were informed about the study and given the opportunity to opt out.
Consent to publish: No identifiable individual data are included in this manuscript.