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First Online: 22 August 2019

Compliance with Ethical Standards

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: R Schubert is employee of the George-Huntington-Institute and is involved in analysis and development of Q-Motor measures. He received funding from the EU-FP7 consortium REPAIR-HD to develop Q-Motor-based quantitative cognitive assessments.T Klockgether receives/has received research support from the Deutsche Forschungsgemeinschaft (DFG), the Bundesministerium für Bildung und Forschung (BMBF), the Bundesministerium für Gesundheit (BMG), the Robert Bosch Foundation, the European Union (EU) and the National Institutes of Health (NIH). He has received consulting fees from Biohaven and UBC. He has received a speaker honorarium from Novartis.R Reilmann is founding director and owner of the George-Huntington-Institute, a private research institute focused on clinical and preclinical research in Huntington disease, and QuantiMedis, a clinical research organisation providing Q-Motor (quantitative motor) services in clinical trials and research. He holds appointments at the Dept. of Radiology of the University of Muenster and at the Department of Neurodegenerative Diseases and Hertie-Institute for Clinical Brain Research, University of Tuebingen. Dr. Reilmann serves as elected member of the Steering Committees of the European Huntington Disease Network (EHDN) and the Huntington Study Group (HSG), co-chair of the Task Force on Huntington’s disease and member of the Task Force on Technology of the International Parkinson and Movement Disorder Society (IPMDS). He has provided consulting services, advisory board functions, clinical trial services, quantitative motor analyses and/or lectures for Actelion Pharmaceuticals, Amarin Neuroscience, AOP Orphan Pharmaceuticals, Cure Huntington Disease Initiative Foundation (CHDI), Desitin, Hoffmann-La Roche, IONIS Pharmaceuticals, Ipsen, Lundbeck, Link Medicine, MEDA Pharma, Medivation, Mitoconix, Neurosearch, Novartis AG, Omeros, Pfizer, Prana Biotechnology, Raptor Pharmaceuticals, Siena Biotech, Temmler Pharma, Teva Pharmaceuticals, uniQure, Vaccinex, Wave Life Sciences and Wyeth Pharmaceuticals. He has received grant support from the Bundesministerium für Bildung und Forschung (BMBF), the Cure Huntington Disease Initiative Foundation (CHDI), the Deutsche Forschungsgemeinschaft (DFG), the Deutsches Zentrum für Neurodegeneration und Entzündung (DZNE), the European Union 7th Framework Program (EU-FP7), the European Huntington Disease Network (EHDN), the High-Q-Foundation and the National Science Foundation (NSF).All other authors declare that they have no conflict of interest.

: All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

: Informed consent was obtained from all individual participants included in the study.