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Authors
Bustamante, M. Leonor https://orcid.org/0000-0001-9071-2463
Miranda, Marcelo
Pellerin, David
Barreto, Mariana
Silva, Claudia
Miranda, Ana C.
Pizarro-Galleguillos, Benjamín
Azaldegui, Octavio
Besa, Valentina
Canals, Francisca
Contreras, María Eugenia
Dicaire, Marie-Josée
Dominik, Natalia
Iruzubieta, Pablo
Danzi, Matt C.
Zuchner, Stephan
Houlden, Henry
Brais, Bernard
Fernández, Ramiro
Fuentes Manríquez, José
Gajardo, Javiera
León, Javiera
Melo, Camila
Muñoz-Chesta, Daniela
Pizarro, Ximena
Rodríguez, Pablo
Salles, Philippe
Sepúlveda, Camilo
Tirapegui, José Miguel
Valenzuela, Daniel
Vial, Felipe
Orellana Pineda, Patricia
Garrido, Cristian
Miranda, Gonzalo
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Funding
Funding for this research was provided by:
Clínica MEDS (Fondo Semilla de Investigación)
Canadian Institutes of Health Research (189963)
Agencia Nacional de Investigación y Desarrollo (Beca de Doctorado Nacional)
NIHR UCLH BRC
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Article History
Received: 11 July 2025
Accepted: 16 November 2025
First Online: 22 December 2025
Declarations
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: All procedures performed in this study were in accordance with the ethical standards of the institutional review board of Universidad de Chile, where the study was carried out, with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The study protocol,"Creación de una Unidad de Enfermedades sin Diagnóstico en la Universidad de Chile” was reviewed and approved by the Comité de Ética de la Investigación en Seres Humanos (CEISH) de la Facultad de Medicina de la Universidad de Chile (Protocol N° 092-2021), on October 12 th , 2021, and renewed on April 11 th 2023. Prior to participation, all individuals provided written informed consent after receiving a comprehensive explanation of the study’s purpose, procedures, potential risks, and benefits. Participant confidentiality and privacy were rigorously maintained throughout the study, with all data being anonymized to protect personal identities.
: Not applicable.
: The authors declare no competing interests.
