Garcia, Gabriel
van Dijkman, Sven C. http://orcid.org/0000-0002-2799-7643
Pavord, Ian http://orcid.org/0000-0002-4288-5973
Singh, Dave
Oosterholt, Sean http://orcid.org/0000-0002-4346-0088
Fulmali, Sourabh
Majumdar, Anurita http://orcid.org/0000-0002-8047-9378
Della Pasqua, Oscar http://orcid.org/0000-0002-6211-1430
Funding for this research was provided by:
GlaxoSmithKline
Article History
Received: 29 April 2024
Accepted: 29 May 2024
First Online: 25 June 2024
Declarations
:
: Ian Pavord has received honoraria for speaking at sponsored meetings from AstraZeneca, Boehringer Ingelheim, Aerocrine, Almirall, Novartis, Teva, Chiesi, Sanofi/Regeneron, Menarini and GSK, and payments for organising educational events from AstraZeneca, GSK, Sanofi/Regeneron and Teva; he has received honoraria for attending advisory panels with Genentech, Sanofi/Regeneron, AstraZeneca, Boehringer Ingelheim, GSK, Novartis, Teva, Merck, Circassia, Chiesi and Knopp and payments to support FDA approval meetings from GSK; he has received sponsorship to attend international scientific meetings from Boehringer Ingelheim, GSK, AstraZeneca, Teva and Chiesi; he has received a grant from Chiesi to support a phase 2 clinical trial in Oxford; he is co-patent holder of the rights to the Leicester Cough Questionnaire and has received payments for its use in clinical trials from Merck, Bayer and Insmed; and in 2014–2015 he was an expert witness for a patent dispute involving AstraZeneca and Teva; Dave Singh has received personal fees from Aerogen, AstraZeneca, Boehringer Ingelheim, Chiesi, Cipla, CSL Behring, Epiendo, Genentech, GSK, Glenmark, Gossamerbio, Kinaset, Menarini, Novartis, Pulmatrix, Sanofi, Synairgen, Teva, Theravance and Verona; Gabriel Garcia has participated in advisory boards for GSK, AstraZeneca, Sanofi, Novartis and Boehringer Ingelheim; he has received honoraria for speaking at sponsored meetings from GSK, Boehringer Ingelheim, AstraZeneca, Sanofi, Phoenix, and Novartis; and is a principal investigator in trials sponsored by GSK, Boehringer Ingelheim, AstraZeneca, Novartis, Sanofi, PPD, Zambon, Parexel, Covance, IQVIA, and Chiesi; Sean Oosterholt, Sven van Dijkman, Sourabh Fulmali, Anurita Majumdar and Oscar Della Pasqua are GSK employees and hold stocks/shares in GSK.
: This article is based on in silico modelling and simulation and does not contain any new studies with human participants or animals performed by any of the authors. All clinical data used for the development and validation of the models describing individual symptom score trajectories, reliever medication use and time to first exacerbation, as well as those required for generating baseline characteristics for the virtual cohorts were derived from clinical trials, which have been performed according to the Declaration of Helsinki and were approved by the required ethics committee(s) and/or ethics review board(s). Re-use of the data for the purpose of the current investigation is in alignment with the terms of informed consent.