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Article History

Received: 17 December 2024

Accepted: 11 April 2025

First Online: 19 May 2025

Declarations

:

: Penny Asbell provides research support and is a consultant for Regeneron Pharmaceuticals Inc. Esen Akpek provides research support to Regeneron Pharmaceuticals Inc. Winston Chamberlain is a medical advisor to Aslan Pharmaceuticals, Beyeonics Surgical, Glaukos Corporation, Immunogen, Kedrion Biopharma, LEO Pharma, Noveome Biotherapeutics, Pfizer, and Viatris; and provides research support to Cambium, Emmecell, Kowa Pharmaceuticals, Regeneron Pharmaceuticals Inc., and ReGenTree. Zhen Chen, Emma Lawless, and Brad Shumel are employees and shareholders of Regeneron Pharmaceuticals Inc. Michael Van Spall, Zafer E. Ozturk are Sanofi employees and may hold stock and/or stock options in the company.

: This study was conducted in accordance with the protocol and consensus ethical principles derived from international guidelines including the Declaration of Helsinki, CIOMS International Ethical Guidelines, applicable ICH GCP Guidelines, and other applicable laws and regulations. The protocol was reviewed and approved by institutional review boards/ethics committees at all centers (Advarra IRB, University of Tennessee Health Centre IRB, and John Hopkins Medical IRB). Each participant provided written informed consent prior to his/her participation in the study. Consent for publication was obtained from all patients whose clinical photographs are included.