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Article History

Received: 8 May 2025

Accepted: 2 July 2025

First Online: 6 August 2025

Declarations

:

: Cyrille Touzeau: Honoraria – AbbVie, Amgen, Bristol Myers Squibb/Celgene, Janssen, Pfizer, Sanofi, Takeda; consulting or advisory role – AbbVie, Amgen, Bristol Myers Squibb/Celgene, Janssen, Pfizer, Takeda; research funding – Sanofi (Inst); travel, accommodations, expenses – Johnson & Johnson/Janssen, Pfizer, Sanofi. Brea Lipe: Consulting or advisory role – AbbVie, GlaxoSmithKline, Janssen, Karyopharm Therapeutics, Pfizer, Sanofi; research funding – Amgen. Abdullah M Khan: Speakers’ bureau – Amgen, Sanofi; research funding – Bristol Myers Squibb, Sanofi; travel, accommodations, expenses – Bristol Myers Squibb. Binod Dhakal: Consulting or advisory role – Amgen, Arcellx, Genentech/Roche, GlaxoSmithKline, Janssen Oncology, Natera, Pfizer, Sanofi, Pfizer, Takeda; speakers bureau – Janssen Oncology; honoraria – Celgene, GlaxoSmithKline, Karyopharm Therapeutics, Sanofi; research funding – Amgen (Inst), Arcellx (Inst), CARsgen Therapeutics (Inst), Bristol Myers Squibb/Celgene (Inst), GlaxoSmithKline, Janssen Oncology (Inst), Sanofi (Inst). Man Zhao: Employment – Haisco Pharmaceutical (I), IQVIA, Janssen; research funding – Haisco Pharmaceutical (I); patents, royalties, other intellectual property – Haisco Pharmaceutical (I). Xavier Leleu: Honoraria – Bristol Myers Squibb, Takeda. Noemí Puig: Honoraria – Amgen, Celgene, Janssen, Pfizer, Sanofi, Takeda, The Binding Site; consulting or advisory role – Amgen, Celgene, Janssen, Pfizer, Sanofi, Takeda, The Binding Site; speakers bureau – Celgene; research funding – Amgen, Celgene, Janssen, Pfizer, Takeda; travel, accommodations, expenses – Amgen, Celgene, Janssen, Pfizer, Takeda, The Binding Site. Dominik Dytfeld: Honoraria – Amgen, Bristol Myers Squibb, GlaxoSmithKline, Janssen, Pfizer; consulting or advisory role – Amgen, Bristol Myers Squibb, GlaxoSmithKline, Janssen, Pfizer; research funding – Bristol Myers Squibb, Janssen; travel, accommodations, expenses – Amgen, Janssen, Bristol Myers Squibb, Pfizer. Elena Zamagni: Honoraria and advisory role – Amgen, Bristol Myers Squibb, GlaxoSmithKline, Janssen, Menarini-Stemline, Oncopeptides, Pfizer, Sanofi. Katja Weisel: Honoraria – AbbVie, Adaptive Biotechnologies, Amgen, Bristol Myers Squibb, Celgene, GlaxoSmithKline, Janssen (Inst), Janssen-Cilag, Karyopharm Therapeutics, Menarini, Novartis, Oncopeptides, Pfizer, Roche, Sanofi, Stemline Therapeutics, Takeda; consulting or advisory role – Adaptive Biotechnologies, Amgen, Bristol Myers Squibb, Celgene, GlaxoSmithKline, Janssen-Cilag, Karyopharm Therapeutics, Menarini, Oncopeptides, Roche, Sanofi, Takeda; research funding – AbbVie (Inst), Amgen (Inst), Bristol Myers Squibb/Celgene (Inst), Celgene (Inst), GlaxoSmithKline (Inst), Janssen-Cilag (Inst), Sanofi (Inst); travel, accommodations, expenses – Amgen, Bristol Myers Squibb, Celgene, GlaxoSmithKline, Janssen-Cilag, Menarini, Takeda. Lionel Karlin: Honoraria – AbbVie, Amgen, Celgene, Johnson & Johnson, Takeda; consulting or advisory role – Amgen, Celgene, Johnson & Johnson, Takeda; travel, accommodations, expenses – Amgen, Johnson & Johnson. Michel Delforge: Honoraria – Amgen, Bristol Myers Squibb, GlaxoSmithKline, Johnson & Johnson; consulting or advisory role – Johnson & Johnson. Paolo Corradini: Honoraria – AbbVie, Amgen, Celgene, Gilead/Kite, Janssen, Novartis, Roche, Sanofi, Takeda; consulting or advisory role – AbbVie, ADC Therapeutics, Amgen, BeiGene, Celgene, Daiichi Sankyo, Gilead/Kite, GlaxoSmithKline, Incyte, Janssen, Kyowa Kirin, Nerviano Medical Science, Novartis, Roche, Sanofi, Takeda. Roberto Mina: Honoraria – AbbVie, Amgen, Bristol Myers Squibb, Janssen Pharmaceuticals, Sanofi; consulting or advisory role – Bristol Myers Squibb, GlaxoSmithKline, Janssen-Cilag EMEA, Janssen Pharmaceuticals, Pfizer, Takeda. Wilfried Roeloffzen: Honoraria – Amgen (Inst), Fondation Sanofi Espoir (Inst), Janssen Biotech (Inst); consulting or advisory role – Bristol Myers Squibb (Inst); travel, accommodations, expenses – AbbVie. Surbhi Sidana: Consulting or advisory role – AbbVie, BiolineRx, Bristol Myers Squibb/Celgene, Genentech/Roche, Janssen, Kite/Gilead, Legend Biotech, Pfizer, Regeneron, Sanofi; research funding – AbbVie (Inst), Allogene Therapeutics (Inst), Bristol Myers Squibb/Celgene (Inst), Janssen (Inst), Magenta Therapeutics (Inst), Novartis (Inst). Sandhya Nair, Seina Lee, Carolina Lonardi, and Diana Chen: Employment – Johnson & Johnson. Jianming He, João Mendes, Ana Slaughter, Nikoletta Lendvai, Jordan M Schecter, and Tzu-min Yeh: Employment – Johnson & Johnson; stock and other ownership interests – Johnson & Johnson.

: CARTITUDE-4 was conducted in accordance with the Declaration of Helsinki and International Conference on Harmonisation Guidelines for Good Clinical Practice. The independent ethics committee or institutional review board at each site approved the protocol (Supplemental Table ). All patients provided written informed consent.