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Article History

Received: 25 June 2025

Accepted: 22 July 2025

First Online: 28 August 2025

Declarations

:

: Medical writing support was provided by Jay Parekh, PharmD, ISMPP CMPP™, of JB Ashtin, and funded by AbbVie.

: Gerd R Burmester reports consulting fees from AbbVie, Amgen, Bristol Myers Squibb, Galapagos, Lilly, Pfizer, and Sanofi; and speaker fees from AbbVie, Amgen, Bristol Myers Squibb, Chugai, Galapagos, Lilly, Pfizer, and Sanofi. Atul Deodhar has received speaker fees from Johnson & Johnson, Novartis, Pfizer, and UCB; consulting fees from Bristol Myers Squibb, Johnson & Johnson, Lilly, MoonLake, Novartis, Pfizer, and UCB; and grant/research support from Bristol Myers Squibb, Johnson & Johnson, Lilly, MoonLake, Novartis, Pfizer, and UCB. Alan D Irvine has received grants, consulting fees, and/or advisory board honoraria from AbbVie, Almirall, Arena, Benevolent AI, Connect Biopharma, Janssen, LEO Pharma, Lilly, Novartis, Pfizer, RAPT Therapeutics, Regeneron, Sanofi, and UCB. He is on the board of directors of the International Eczema Council. Remo Panaccione has received consulting fees from AbbVie, Abbott, Abbivax, Alimentiv, Amgen, AnaptysBio, AstraZeneca, Biogen, Boehringer Ingelheim, Bristol Myers Squibb, Celgene, Celltrion, Cosmos Pharmaceuticals, Eisai, Elan, Ferring, Fresenius Kabi, Galapagos, Inviva, Genentech, Gilead Sciences, GSK, JAMP Bio, Janssen, Lilly, Merck, Mirador, Novartis, Oppilan Pharma, Odyssey, Organon, Pandion Pharma, Pendopharm, Pfizer, Progenity, Prometheus Biosciences, Protagonist Therapeutics, Roche, Sandoz, Sanofi, Satisfai Health, Shire, Spyre Therapeutics, Sublimity Therapeutics, Takeda, Teva, Tillots, Trellus, Union Biopharma, Viatris, Ventyx, and UCB; speaker fees from AbbVie, Amgen, Arena Pharmaceuticals, Bristol Myers Squibb, Celgene, Ferring, Fresenius Kabi, Gilead Sciences, Janssen, Lilly, Merck, Organon, Pfizer, Roche, Sandoz, Shire, Takeda; and has served on advisory boards for AbbVie, Alimentiv, Amgen, Arena Pharmaceuticals, AstraZeneca, Biogen, Boehringer Ingelheim, Bristol Myers Squibb, Celgene, Ferring, Fresenius Kabi, Genentech, Gilead Sciences, GSK, JAMP Bio, Janssen, Lilly, Merck, Mylan, Novartis, Oppilan Pharma, Organon, Pandion Pharma, Pfizer, Progenity, Protagonist Therapeutics, Roche, Sandoz, Sanofi, Sublimity Therapeutics, Takeda, and Ventyx. Kevin L Winthrop has received consulting fees, grants and/or research support from AbbVie, AstraZeneca, Bristol Myers Squibb, Galapagos, Gilead, GSK, Lilly, Novartis, Pfizer, Regeneron, Roche, Sanofi, and UCB. Ruth Ann Vleugels is an investigator and/or consultant for AbbVie, AstraZeneca, Lilly, Pfizer, and Priovant. Gweneth Levy, Smitha Suravaram, Hannah Palac, Lani Wegrzyn, Sharanya Ford, and Sebastian Meerwein are full-time employees of AbbVie, and may hold AbbVie stock and/or stock options. Emma Guttman-Yassky is an employee of Mount Sinai and has received research grants (paid to the institution) from and/or a consultant for AbbVie, Aclaris, Almirall, Alumis, Amgen, AnaptysBio, Apogee, Apollo, Arcutis, Artax, Astria, Boehringer Ingelheim, Bristol Myers Squibb, Celldex, Centrexion, Concerto, Connect, Coty, DBV, Dualitas, Enveda, Escient, Galderma, Gate Bio, GSK, Incyte, Inmagene, Janssen, Jasper, Kymera, Kyowa Kirin, LEO Pharma, Lilly, Matchpoint, Merck, Nektar, NUMAB, Opsidio, OTSUKA, Pfizer, Pharmaxis, Proteologix, Q32 Bio, RAPT, RayThera, Regeneron, Ribon, Sanofi, SATO, Schrödinger, Sitryx, Sun Pharma, Takeda, Teva, TRex, UCB, VRG Therapeutics, and Xencor.

: All studies were conducted in accordance with the Declaration of Helsinki, the International Council for Harmonisation guidelines, and applicable local regulations. An independent ethics committee or institutional review board at each study site approved the protocol. Patients (or legal guardians of adolescents) provided written informed consent before beginning the study.