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Article History

Received: 6 March 2025

Accepted: 20 October 2025

First Online: 21 November 2025

Declarations

:

: Lauren Lilly, Chuka Udeze, Carlos Penaranda, and Nanxin Li are employees of Vertex Pharmaceuticals Incorporated and may own stock or stock options in the company. Natalie Nightingale, Irene Wang, Jillian Murphy, and Calum S. Neish are consultants from IQVIA, who were paid contractors to Vertex Pharmaceutical Incorporated in this study. Kevin H.M. Kuo is now affiliated with Scarborough Health Network Research Institute; Toronto, Ontario, CA. He discloses consultancy work for Agios Pharmaceuticals, Alexion Pharmaceuticals, Biossil Inc, Bristol-Myers Squibb, Novo Nordisk, Pfizer Inc, and Vertex Pharmaceuticals; has received research funding from Agios Pharmaceuticals and Pfizer Inc; and holds membership on a Board or Advisory Committee at Bioverativ/Sanofi/Sangamo.

: This study contracted ICES Data & Analytic Services (DAS) and used de-identified data from the ICES Data Repository, managed by ICES with support from its funders and partners: Canada’s Strategy for Patient-Oriented Research (SPOR), the Ontario SPOR Support Unit, the Canadian Institutes of Health Research, and the Government of Ontario.

: This study used de-identified data from the ICES Data Repository. The authors do not own the data. Data are owned by ICES, and we do not have access to raw data. As such, it has not been made available on a public site. Raw outputs will be on the ICES website per the agreement with ICES. Requests for data can be made to the ICES Data Repository.