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Article History

Received: 21 November 2024

Accepted: 28 December 2024

First Online: 15 January 2025

Declarations

:

: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

: All experiments were conducted in accordance with the Ethics Committee of the Laboratory Animal Center of Tokyo Medical University (Approval number; No. R6-069), and all animal handling procedures conformed to acceptable guidelines on the ethical use of animals in this research.

: All authors had full access to all the data in the study and take responsibility for the integrity of data and the accuracy of the data analysis. Iwao Sato/Conceptualization; Ryutaro Nakagawa /Data curation; Iwao Sato, Shinichi Kawata, Yutaro Natsuyama, and Yoko Ueda/Formal analysis; Iwao Sato and Masahiro Itoh/Funding acquisition; Iwao Sato, Yoko Ueda, and Ryutaro Nakagawa/Investigation; Iwao Sato, Yutaro Natsuyama, and Hidenobu Miyaso/Methodology; Iwao Sato and Masahiro Itoh/Project administration; Ryutaro Nakagawa, and Zhong-Lian Li/Resources; Shinichi Kawata/Software; Masahiro Itoh/Supervision; Tomiko Yakura, and Yoko Ueda/Validation; Iwao Sato, Ryutaro Nakagawa, Tomiko Yakura and Hidenobu Miyaso/Visualization; Iwao Sato and Ryutaro Nakagawa/Writing – original draft; Iwao Sato, Ryutaro Nakagawa, Zhong-Lian Li, Hidenobu Miyaso, and Masahiro Itoh/Writing – review and editing.