Ojiro, Ryota https://orcid.org/0000-0002-4480-5252
Takahashi, Yasunori
Tang, Qian https://orcid.org/0009-0001-8369-9798
Sakamaki, Yuri
Shobudani, Momoka
Zou, Xinyu https://orcid.org/0000-0001-8551-9319
Kobayashi, Mio
Ebizuka, Yuri
Kigata, Tetsuhito https://orcid.org/0000-0002-2219-9634
Shibutani, Makoto https://orcid.org/0000-0003-3417-9697
Funding for this research was provided by:
Ministry of Health, Labour and Welfare (22KD1002)
Article History
Received: 2 June 2025
Revised: 14 October 2025
Accepted: 10 December 2025
First Online: 24 December 2025
Declarations
:
: The authors declare no competing interests.
: The experimental procedures of animal studies were conducted strictly following the Guide for the Care and Use of Laboratory Animals outlined by the National Academy of Sciences of the United States of America (NIH Publication No. 8023, revised 1978). The procedures were conducted in compliance with the approved experimental protocol by the Animal Care and Use Committee of the Tokyo University of Agriculture and Technology (Approved Nos. 30-60, 31-21, R02-81, and R202-80). In addition, the reporting of animal experiments followed the ARRIVE guidelines. Every possible measure was taken to minimize animal distress.