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Article History

Received: 30 July 2024

Accepted: 30 September 2024

First Online: 4 October 2024

Declarations

:

: The animal study was conducted in accordance with the ethical standards and guidelines set forth by the Ethics Committee of Jinzhou Medical University. The study protocol was reviewed and approved by the Ethics Committee, with the permit number: 240110. All procedures performed in this study involving animals were in compliance with the ARRIVE guidelines and the guidelines of the National Institutes of Health for the care and use of laboratory animals. The maximal tumor size permitted by our institutional ethics committee guidelines is 2 cm in diameter, or any tumor burden that does not cause significant discomfort, impaired mobility, or affect the well-being of the animal. We confirm that the maximal tumor size/burden as outlined by our ethics committee was not exceeded at any point during the study. In all cases, animals were closely monitored, and any discomfort or significant tumor growth was addressed promptly. In instances where tumors approached the size limit, animals were euthanized following the approved humane endpoints to avoid exceeding the permitted tumor burden.

: The authors declare no competing interests.