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Authors
Huang, Hai-yi
Lin, Lisa Zong Yong
Lu, Xin-yi
Jiang, Ying
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Funding
Funding for this research was provided by:
General Program of Natural Science Foundation of Fujian Provincial (2022J011416)
Science and Technology Program Guidance Project, Xiamen, Fujian (35022202142D1067)
Wu Jieping Medical Foundation (320.6750.2024-21-35)
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Article History
Received: 17 January 2025
Accepted: 2 May 2025
First Online: 8 May 2025
Declarations
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: All animal procedures were approved by the Shanghai Model Organisms Center Institutional Animal Care and Use Committee (SRCMO-IACUC) (NO.2024-0003), with the maximal permitted tumor burden not exceeding 1000 mm3 in volume (calculated as length × width2 × 0.5) or 10% of body weight. Throughout the study, tumor dimensions were monitored using calipers, and no animals exceeded the approved tumor size limits. At the experimental endpoint, mice were rapidly euthanized by cervical dislocation. This method was selected for its rapidity (< 5 s to unconsciousness) and compatibility with tissue collection requirements. Death was confirmed by absence of corneal reflex and cessation of breathing for > 1 min. All procedures adhered to the SRCMO-IACUC guidelines.
: The authors declare no competing interests.
