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Single-cell RNA sequencing reveals NFATc1-mediated regulatory mechanisms of vascular smooth muscle cell osteogenic transformation in the osteosarcoma microenvironment

Crossref DOI link: https://doi.org/10.1007/s12672-025-03606-9

Published Online: 2025-09-29

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Yi, Xuejiao

Fu, Shilin

Zhang, Chunliang

Zhao, Tianle

Feng, Huan

Qian, Dehui
Funding

Funding for this research was provided by:

the General Program of Chongqing Natural Science Fund (CSTB2023NSCQ-MSX0686, CSTB2023NSCQ-MSX0686)

the Youth Doctor Talent Incubation Program of the Second Affiliated Hospital of Army Medical University (2022YQB029, 2022YQB029)

the Key Support Targets for The University's Talent Pool in 2019 (2019R015, 2019R015)
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Text and Data Mining valid from 2025-09-29

Version of Record valid from 2025-09-29
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Article History

Received: 16 July 2025

Accepted: 8 September 2025

First Online: 29 September 2025

Declarations

:

: This study did not involve human participants, tissues, or identifiable data. All experiments were conducted using established cell lines. Therefore, ethical approval and informed consent were not required.

: All the authors reviewed and approved the final manuscript.

: The authors declare no competing interests.

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