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Article History

Received: 20 May 2025

Accepted: 25 November 2025

First Online: 10 December 2025

Declarations

:

: Ethical approval for the use of human tissue was obtained from the Ethics Committee of the university of Freiburg. All procedures were performed in accordance with relevant guidelines and regulations. was performed in accordance with the ethical standards as laid down in the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards. In accordance with the statement of the ethics committee (EK 10/12) of the University Medical Center Freiburg, individual written consent of the included patients was not required, as the material had been previously used for routine diagnostic purposes and had been archived for at least 3 years. For this retrospective study, the requirement for individual informed consent was waived by the ethics committee. Since no images or information presented in this article permitted the identification of individual participants, no specific consent for publication was required by the ethics committee.

: Consent to publish declaration: not applicable.

: The authors declare no competing interests.