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Integrative single-cell RNA-seq and transcriptomic analysis uncovers cellular heterogeneity and immunotherapy resistance mechanisms in colorectal cancer

Crossref DOI link: https://doi.org/10.1007/s12672-026-05284-7

Published Online: 2026-05-25

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Wang, Yirou

Zhang, Yingying

Mao, Ziyong

Du, Wenle

Cao, Xiyuan

Jiang, Minxuan

Zhang, Qingchen

Zhan, Shenghua

Chen, Zutao
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Text and Data Mining valid from 2026-05-25

Accepted Manuscript valid from 2026-05-25
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Article History

Received: 8 January 2026

Accepted: 14 May 2026

First Online: 25 May 2026

Declarations

:

: The study was approved by The Fourth Affiliated Hospital of Soochow University(Suzhou Dushu Lake Hospital) Clinical Trial Medical Ethics Committee(Reference number: 251172)and conducted in accordance with the Declaration of Helsinki. All subjects gave written informed consent before participating in the study. This research was conducted exclusively with de-identified, publicly accessible datasets (GEO and TCGA). No additional informed consent was required.

: Not applicable.

: The authors declare no competing interests.

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