van Dijk, Bart J.
Meijers, Joost C.M.
Kloek, Anne T.
Knaup, Veronique L.
Rinkel, Gabriel J.E.
Morgan, B. Paul
van der Kamp, Marije J.
Osuka, Koji
Aronica, Eleonora
Ruigrok, Ynte M.
van de Beek, Diederik
Brouwer, Matthijs
Pekna, Marcela
Hol, Elly M.
Vergouwen, Mervyn D.I.
Funding for this research was provided by:
Hartstichting (2011T18)
Article History
Received: 5 June 2019
Revised: 29 October 2019
Accepted: 19 November 2019
First Online: 6 December 2019
Compliance with Ethical Standards
: Written informed consent was obtained from all participating patients or their legally authorized representatives, and controls. Approval for the genetic study was obtained from the Institutional Research Ethics Board, University Medical Center Utrecht, Utrecht, the Netherlands. All procedures performed in studies involving human participants were in accordance with the ethical standards of the Institutional Research Ethics Board and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. All animal experiments were approved by the Institutional Animal Care and Use Committee of the Academic Medical Center, Amsterdam, the Netherlands.
: A patent was filed by the University Medical Center Utrecht, based on the data described in this manuscript (Methods of reducing brain injury after aneurysmal subarachnoid hemorrhage using anti-C5 or anti C5a antibodies [application number 62820860]).