Koseki, Hirokazu
Miyata, Haruka
Shimo, Satoshi
Ohno, Nobuhiko
Mifune, Kazuma
Shimano, Kenjiro
Yamamoto, Kimiko
Nozaki, Kazuhiko
Kasuya, Hidetoshi
Narumiya, Shuh
Aoki, Tomohiro http://orcid.org/0000-0002-1578-1394
Funding for this research was provided by:
Japan Agency for Medical Research and Development (JP18gm0810006)
Article History
Received: 24 September 2018
Revised: 20 December 2018
Accepted: 22 January 2019
First Online: 8 February 2019
Compliance with Ethical Standards
:
: T. A. was supported by the Coordination Fund from the Japanese Ministry for Education, Culture, Sports, Science and Technology (MEXT) and Astellas Pharma Inc. to Kyoto University until 31th/March/2017 and S.N. is supported by a same grant. S.N. is a scientific advisor to Astellas Pharma. H. K., H. M., S. S., N.O., K. M., K. S., K. Y., K. N., and H. K. declare that they have no conflict of interest.
: All applicable international, national, and/or institutional guidelines for the care and use of animals were followed. And this study was approved by the Institutional Animal Care and Use Committee of Kyoto University Graduate School of Medicine and also of National Cerebral and Cardiovascular Center. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. This study was approved by the Institutional Review Board of Shimizu Hospital (Kyoto, Japan, Approval No. 203). Informed consent was obtained from all individual participants included in the study.