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Article History

Received: 24 May 2024

Accepted: 16 July 2024

First Online: 21 August 2024

Declarations

:

: Any disclosure.

: The study was approved by the Ethical Committee (n 39/2022 Joint EC S Luigi Hospital, ASLTO3, TO4 and TO5) and conducted at the Thoracic Surgery Division of S Luigi Gonzaga Hospital, University of Turin, Italy, in cooperation with the Pathology Division of the same Institution and the Epithelial Stem Cell Biology and Regenerative Medicine Laboratory of the Crick Institute, London, UK. All the biopsies were performed after acquisition of informed consent. The authors did not receive support from any organization for the submitted work.

: Mice were kept, managed, and killed at the Molecular Biotechnology Center (MBC) Animal Facility of the University of Torino, according to current European (2007/526/CE) legislation in accordance with the guideline for Ethical Conduct in the Care and Use of Animals as stated in The International Guiding Principles for Biomedical Research Involving Animal. The mice were housed in cages with adequate space, bedding material for comfort and maintained under specific pathogen-free conditions, maintaining 12-h dark/light cycle. All experiments were approved by the Italian Health Minister (authorization n° 1227/2020-PR).