Morse, James D. http://orcid.org/0000-0001-7500-0062
Stanescu, Ioana
Atkinson, Hartley C.
Anderson, Brian J. http://orcid.org/0000-0002-2826-3019
Funding for this research was provided by:
AFT Pharmaceuticals Limited
University of Auckland
Article History
Accepted: 10 March 2022
First Online: 2 April 2022
Declarations
:
: JDM and BJA have no conflicts of interest to declare. HA and IS are employees and shareholders in AFT Pharmaceuticals.
: Open Access funding enabled and organized by CAUL and its Member Institutions. This work was funded by AFT Pharmaceuticals Limited, Auckland, New Zealand. This work was performed using a license for NONMEM granted by ICON to the Australian Centre of Pharmacometrics. The Australian Centre for Pharmacometrics is an initiative of the Australian Government as part of the National Collaborative Research Infrastructure Strategy. James Morse is supported in part by the New Zealand Society of Anaesthetists Ritchie Prize.
: These studies were approved by the Jordan Food and Drug Administration and were registered with the Australian New Zealand Clinical Trial Registry (AFT-MXIV-01—ACTRN12614000809639; AFT-MXIV-06—ACTRN12615001208594; AFT-MX-14a—ACTRN12616000418471; AFT-MX-14b—ACTRN12616000419460).
: Written informed consent was given by all participants.
: The data that support the findings of this study are available from the corresponding author upon reasonable request.
: Not applicable.
: NM-TRAN control streams are available on request.
: All authors whose names appear on the submission made substantial contributions to the conception or design of the work, the acquisition, analysis, interpretation of data used in the work. All authors revised it critically for important intellectual content, approved the version to be published; and agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.