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Article History

Accepted: 19 April 2022

First Online: 15 July 2022

Declarations

:

: The activities of Certara UK Limited, Simcyp Division is supported by the Simcyp Consortium of pharmaceutical companies. No other source of funding was used for the work.

: Peter Kilford—at the time of the work was employed by Certara UK Limited and may hold shares in the company. Nika Khoshaein—at the time of the work was employed by Certara UK Limited and may hold shares in the company. Roz Southall—is employed by Certara UK Limited and may hold shares in the company. Iain Gardner—is employed by Certara UK Limited and may hold shares in the company.

: This was a simulation study and did not involve any clinical studies and therefore ethics approval was not needed.

: The datasets generated during and/or analysed during the current study are available from the corresponding author on reasonable request.

: The workspaces used to run the simulation are available from the corresponding author on reasonable request.

: Not applicable.

: Not applicable.

: PK, NK, RS, IG wrote the manuscript; PK, NK designed the research; PK, NK, RS, IG performed the research; PK, NK analysed the data