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Article History

Accepted: 10 July 2022

First Online: 26 July 2022

Declarations

:

: This research work was funded by Zydus Lifesciences Limited (ZLL).

: The experiments on animals have been performed as per applicable ethical guidance. The procedures on mice (ZRC/DMPK/BP/005/07-2K13) and rats (ZRC/DMPK/BP/003/03-2K13) were approved by the Institutional Animal Ethics Committee (IAEC) of the Zydus Research Centre, Zydus Lifesciences Limited, Ahmedabad, India, and protocols for dog (ZRC/DMPK/NP/008/03-2K13) and monkey (ZRC/PRF/NP/015/12-2K12) were approved by the committee for the purpose of control and supervision of experiments on animals (CPCSEA), Government of India.

: All the authors are employees of Zydus Lifesciences Limited and have no conflicts of interest in the content of the research work (ZRC communication number 670).

: Not applicable.

: Not applicable.

: Data supporting the findings are available from the corresponding author upon request.

: The proprietary software program Phoenix WinNonlin and GraphPad Prism was used for the data calculation and analysis reported here.

: Participated in research design, manuscript writing, and interpretation of the data: H.P., P.G., P.P., V.P., R.C., and M.J.; conducted experiments and data analysis: N.M., J.C., P.P., and H.P.