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Article History

Accepted: 25 April 2023

First Online: 18 May 2023

Declarations

:

: No funding was received for this work.

: Three of the authors (T.Y., T.H., and K.U.) declare conflicts of interest based on their relationships with Stella Pharma Corporation. The remaining authors have no conflicts of interest to declare.

: The raw data before analysis can be downloaded as supplementary data in this manuscript.

: Not applicable. No special codes were used in the analysis of this study’s data.

: Not applicable.

: Not applicable.

: K.O., T.H., and K.U. conceived and designed the study. T.Y., H.T., Y.K., G.K., S.-I. M., and S. M. performed experiments and data analyses. T.W. performed additional data analyses. K.O., and S. M. supervised the project. T.W., T.H., and K.U. wrote the manuscript. All authors edited and approved the manuscript.

: The mice used in this study were cared for and treated according to the Recommendations for the Handling of Laboratory Animals for Biomedical Research by the Committee on Ethical Handling Regulations for Laboratory Animal Experiments, Kyoto University. Additionally, all animal experiments were approved by Ethical Handling Regulations for Laboratory Animal Experiments, Kyoto University (approval no. 200813) and conducted per the laboratory animal handling guidelines of our institution.