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Article History

Accepted: 19 May 2024

First Online: 14 June 2024

Declarations

:

: Alejandra Schiavo: Conceptualization, Methodology, Software, Formal analysis, Investigation, Writing—original draft, Visualization. Pietro Fagiolino: Conceptualization, Investigation, Writing—review & editing. Marta Vázquez: Investigation, Writing—review & editing. Iñaki F. Trocóniz: Conceptualization, Methodology, Software, Writing—review & editing. Manuel Ibarra: Conceptualization, Methodology, Software, Investigation, Formal analysis, Writing—original draft, Visualization, Supervision, Project administration.

: This work was supported by the CAP (Comisión Académica de Posgrado, UDELAR) with a grant to AS as a graduate student. PEDECIBA-Química and CSIC (Comisión Sectorial de Investigación Científica, UDELAR) granted funds to support AS Ph.D. studies.

: The data that support the findings of this study are available from the corresponding author, MI, upon reasonable request.

: All code implemented to perform the analyses contained in this work are available from the corresponding author, MI, upon reasonable request.

: The authors have no conflict of interest to disclose.

: All procedures in this study were in accordance with the 1964 Helsinki declaration (and its amendments). The protocol of the clinical study was previously approved by the Institutional Ethics Review Committee of Faculty of Chemistry (Universidad de la República, Uruguay). Resolution N° 101900-000425-09, June 4th, 2009.

: All subjects enrolled in the study were previously informed of the protocol details and implications and gave their written informed consent prior to study inclusion.

: Not applicable.