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Article History

Accepted: 7 April 2025

First Online: 23 April 2025

Declarations

:

: M.S.C and M.Z conceived the presented idea. H.N and M.Z. provided the clinical data. M.S.C performed the analysis and wrote the manuscript. H.N and M.Z. verified the analytical methods and supervised the findings of this work. All authors discussed the results and contributed to the final manuscript.

: The original clinical study was funded through an unrestricted grant provided by the Paul-Ehrlich Society for Chemotherapy, Germany. Maria Sanz Codina received funding from the European Union’s Horizon 2020 research and innovation program under the Marie Sklodowska-Curie Grant agreement no. 861323.

: Original data is part of the clinical study under registration number DRKS00012985.

: Not applicable.

: None to declare.

: The study was approved by the Ethics Committee of Ruhr-University Bochum (registration number 4830-13) and conducted in compliance with the Declaration of Helsinki as well as applicable national and institutional guidelines. The trial was registered in the German Clinical Trials Register (DRKS) under registration number DRKS00012985.

: Participant inclusion occurred following the acquisition of informed consent from the patient or, in cases where the patient was unable to provide consent (e.g., due to sedation), from their legal representative.

: Not applicable.