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Article History

Accepted: 22 July 2025

First Online: 21 August 2025

Declarations

:

: All authors made substantial contributions to the study conception, data acquisition, analysis, or interpretation. The initial manuscript draft was prepared by Yuxing Huang, with all coauthors contributing to critical revision of the content. All authors approved the final version for submission and assume full responsibility for the academic integrity of this work.

: This trial was sponsored by Tianjin Kangrui Pharmaceutical Co., Ltd.

: Data archiving is not mandated but data will be made available on reasonable request.

: Not applicable.

: Yuxing Huang, Qiuhan Cai, Mei fang Li, Shengxuan Guo, Gaiying Dong, Siyuan Hu and Chengliang Zhong are all employees of the First Teaching Hospital of Tianjin University of Traditional Chinese Medicine. All of the authors declare no conflicts of interest.

: This study protocol was approved by the Medical Ethics Committee at the First Teaching Hospital of Tianjin University of Traditional Chinese Medicine on 23 January 2018 (registration number: TYLL2018Y002).

: All study participants provided written informed consent.

: Not applicable.