Document is current

Article History

Accepted: 8 June 2025

First Online: 18 June 2025

Declarations

:

: All institutional and national guidelines for the care and use of laboratory animals were followed. The experimental protocols were reviewed and approved (reference 0421/000/000/2023 002871) by the competent national authority [Portuguese General Directorate for Food and Veterinary (DGAV– Direção Geral de Alimentação e Veterinária)], in agreement with the regulations of the European Directive 2010/63/EU and Portuguese law (Decreto-Lei nº 113/2013).

: Not applicable.

: Not applicable.

: Adriana O. Santos and Gilberto Alves are inventors on a patent application related with the nanoemulsions described in this manuscript (WO2022259205A1), of which the US national stage application #18/568,879 is pending to Population Council, NY, USA. Regine Sitruk-Ware is an inventor on the use of Nestorone for neuroprotection: United States patent number 9,446,051, to Sitruk-Ware, Schumacher, Brinton, El-Etr, Ghoumari and Guennoun, entitled, “Neuroprotection and Myelin Repair Using Nestorone,” filed December 21, 2012. Issued September 20, 2016; and United States patent number 10,052,335 to Sitruk-Ware, Schumacher, Brinton, El-Etr, Ghoumari and Guennoun, entitled, “Neuroprotection and Myelin Repair Using Nestorone,” filed October 19, 2010. Issued August 21, 2018. Ana Palmeira-de-Oliveira, Rita Palmeira-de-Oliveira own the company disclosed as their affiliation (Labfit-HPRD, Health Products Research and Development Lda, 6200 − 284 Covilhã, Portugal.) and Carlos Gaspar is their employee. Authors Carina Peres, Sara Meirinho, Samille Ferreira da Silva, Izamara Maocha, Anabela Chiangalala, Susana Alves Ferreira, Márcio Rodrigues, Shimin Zhang, Narender Kumar, Rui Caetano Oliveira and Graça Baltazar declare that they have no conflict of interest.