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SARS-CoV-2-induced damage to rat cortical neuronal networks ex vivo is mediated by the pro-inflammatory activation of the cGAS-STING pathway

Crossref DOI link: https://doi.org/10.1007/s13365-025-01283-6

Published Online: 2025-10-25

Published Print: 2025-12

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Martinez-Orellana, Pamela https://orcid.org/0000-0002-2025-9445
Manzati, Matteo https://orcid.org/0000-0003-2434-0088
Pozzi, Diletta https://orcid.org/0000-0001-9396-8050
Xiao, Yingying https://orcid.org/0009-0009-7216-0031
Di Clemente, Alessio https://orcid.org/0000-0001-7129-7882
Mearelli, Marika https://orcid.org/0009-0006-5168-3130
Kalebić, Chiara https://orcid.org/0009-0009-3523-7562
Perrera, Valentina https://orcid.org/0000-0001-9011-3671
Ferrarini, Denise https://orcid.org/0009-0002-8961-6321
Carletti, Tea https://orcid.org/0000-0003-2510-2399
Falcone, Carmen https://orcid.org/0000-0001-9892-1171
Giugliano, Michele https://orcid.org/0000-0003-2626-594X
Marcello, Alessandro https://orcid.org/0000-0002-8903-8202
Funding

Funding for this research was provided by:

Italian National Institute of Health (RIPREI2023_7c8ae10d783c)

NextGenerationEU-MUR PNRR Extended Partnership initiative on Emerging Infectious Diseases (PE00000007, INF-ACT)
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Text and Data Mining valid from 2025-10-25

Version of Record valid from 2025-10-25
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Article History

Received: 16 July 2025

Revised: 6 September 2025

Accepted: 12 September 2025

First Online: 25 October 2025

Declarations

:

: All procedures were performed in accordance with the guidelines of the Italian Animal Welfare Act and their use was approved by the Local Veterinary Service, the SISSA Ethics Committee board, and the National Ministry of Health, in accordance with the European Union guidelines for animal care (Directive 2010/63/EU).

: The authors declare no competing interests.

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